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Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
Cell ( IF 64.5 ) Pub Date : 2022-04-28 , DOI: 10.1016/j.cell.2022.04.001
Ruchi Malik 1 , Yi Li 1 , Selin Schamiloglu 1 , Vikaas S Sohal 1
Affiliation  

Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood. In particular, knowledge about direct prefrontal connections that might facilitate top-down control of hippocampal information processing remains sparse. Here we describe monosynaptic long-range GABAergic projections from PFC to hippocampus. These preferentially inhibit vasoactive intestinal polypeptide-expressing interneurons, which are known to disinhibit hippocampal microcircuits. Indeed, stimulating prefrontal–hippocampal GABAergic projections increases hippocampal feedforward inhibition and reduces hippocampal activity in vivo. The net effect of these actions is to specifically enhance the signal-to-noise ratio for hippocampal encoding of object locations and augment object-induced increases in spatial information. Correspondingly, activating or inhibiting these projections promotes or suppresses object exploration, respectively. Together, these results elucidate a top-down prefrontal pathway in which long-range GABAergic projections target disinhibitory microcircuits, thereby enhancing signals and network dynamics underlying exploratory behavior.



中文翻译:

前额叶长程抑制对海马信噪比的自上而下控制

前额叶皮层 (PFC) 被假定对整个大脑的信息处理施加“自上而下的控制”以促进特定行为。然而,调解自上而下控制的途径仍然知之甚少。特别是,关于可能有助于自上而下控制海马信息处理的直接前额叶连接的知识仍然很少。在这里,我们描述了从 PFC 到海马体的单突触远程 GABAergic 投射。这些优先抑制表达血管活性肠多肽的中间神经元,已知这些中间神经元会抑制海马微电路。实际上,刺激前额叶-海马 GABA 能投射会增加海马前馈抑制并降低体内海马活动. 这些行动的最终效果是特别增强海马体编码对象位置的信噪比,并增强对象引起的空间信息增加。相应地,激活或抑制这些投射分别促进或抑制物体探索。总之,这些结果阐明了一个自上而下的前额叶通路,其中远程 GABAergic 投射靶向去抑制性微电路,从而增强探索行为背后的信号和网络动力学。

更新日期:2022-04-29
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