High-grade gliomas are the most common and most malign primary brain tumors. Current therapy approaches only reach unsatisfactory results, still not providing a long-lasting time to relapse or a curative treatment. A novel approach to overcome the present challenges of medical attendance, as drug resistance, systemic side effects, and limited drug availability due to the blood-brain barrier, are localized drug delivery systems (DDSs), which are already used in clinical trials. Further development of this therapy regime may clearly improve patient's outcomes. In order to design compact, biocompatible, robust, and highly flexible systems which permit a prolonged drug release, a broad knowledge of the technical and medical field is required. Thus, this interdisciplinary article reviews different designs, testing, and validation models, and finally, clinical applications of localized DDSs, to utilize this available experience as a basis for the desperately needed reform of glioma treatment.

中文翻译：

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高级别胶质瘤治疗中的局部给药系统——从构建到应用

高级别胶质瘤是最常见和最恶性的原发性脑肿瘤。目前的治疗方法只能达到不令人满意的结果，仍然不能提供持久的复发时间或治愈性治疗。一种克服目前医疗护理挑战的新方法是局部药物输送系统（DDS），它已经用于临床试验，因为药物耐药性、全身副作用和由于血脑屏障导致的药物可用性有限。这种治疗方案的进一步发展可能会明显改善患者的结果。为了设计允许延长药物释放的紧凑、生物相容、坚固和高度灵活的系统，需要对技术和医学领域有广泛的了解。因此，这篇跨学科文章回顾了不同的设计、测试和验证模型，