Chem ( IF 23.5 ) Pub Date : 2022-04-27 , DOI: 10.1016/j.chempr.2022.04.003 Yong Hu 1 , Chunhai Fan 2
The innovation of DNA hydrogels has led to the development of programmable nanocomposite DNA hydrogels that are now emerging as bioinstructive materials systems for fundamental and applied research at the crossroads of chemistry, materials, and biology. Due to the feasible synthesis of various colloidal materials and DNA-colloid conjugates, nanocomposite DNA hydrogels can be rationally designed and assembled with tunable physiochemical property as well as integrated functionalities, thereby responding to external physical cues, exhibiting catalytic activities, or acting as therapeutic agents. Furthermore, the implementation of such tailorable substrata enables grafting, colonization, and control of eukaryotic and prokaryotic cells for cell-substrate engineering. It can be anticipated that the integration of nanocomposite DNA hydrogels with microfluidic systems or DNA surface technology might facilitate the development of modern integrated systems and platforms for widespread applications in materials and life sciences.
中文翻译:
纳米复合 DNA 水凝胶作为可编程和生物指导材料系统出现
DNA 水凝胶的创新导致了可编程纳米复合 DNA 水凝胶的发展,这些水凝胶现在正在成为化学、材料和生物学交叉领域基础和应用研究的生物指导材料系统。由于各种胶体材料和DNA-胶体共轭物的合成可行,纳米复合DNA水凝胶可以合理设计和组装,具有可调的理化性质和集成功能,从而响应外部物理信号、表现出催化活性或作为治疗剂. 此外,这种可定制的基质的实施使真核和原核细胞的移植、定植和控制能够用于细胞基质工程。