Extending mass spectrometry measurements of biomolecules into the megadalton regime is challenging due to the limited resolving power of currently used mass analysers. Now, using single ion-charge detection Orbitrap mass spectrometry, a mass accuracy of 0.001% has been demonstrated for protein particles larger than 9 MDa.

中文翻译：

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更清楚地看到飞行的分子大象

由于目前使用的质量分析器的分辨能力有限，将生物分子的质谱测量扩展到兆道尔顿范围内具有挑战性。现在，使用单离子电荷检测 Orbitrap 质谱仪，已经证明大于 9 MDa 的蛋白质颗粒的质量精度为 0.001%。