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Mammalian antiviral RNAi is on the move.
The EMBO Journal ( IF 11.4 ) Pub Date : 2022-04-26 , DOI: 10.15252/embj.2022111210
Kristina L Schierhorn 1 , Raul Y Sanchez-David 1 , Pierre V Maillard 1
Affiliation  

Recent work reported the existence of a mammalian cell-autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus-derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. In a new study, Zhang et al (2022) find that, in infected mice, vsiRNAs can enter the bloodstream via their incorporation into extracellular vesicles (EVs) and confer sequence-specific antiviral activity to recipient cells, thus indicating that mammalian antiviral RNAi participates in both cell-autonomous and non-cell-autonomous host defence.

中文翻译:

哺乳动物抗病毒 RNAi 正在进行中。

最近的工作报告了基于 RNA 干扰 (RNAi) 的哺乳动物细胞自主抗病毒防御的存在,它依赖于病毒衍生的小干扰 RNA (vsiRNA) 的积累来指导互补病毒 RNA 的降解。在一项新研究中,Zhang 等人 (2022) 发现,在受感染的小鼠中,vsiRNA 可以通过掺入细胞外囊泡 (EV) 进入血液,并赋予受体细胞序列特异性抗病毒活性,从而表明哺乳动物抗病毒 RNAi 参与在细胞自主和非细胞自主宿主防御中。
更新日期:2022-04-26
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