INTRODUCTION Despite the high prevalence of pediatric obesity, its impact on Crohn's disease (CD) and ulcerative colitis (UC) activity remains poorly characterized. The aim of this study was to evaluate disease-related outcomes in overweight and obese children with CD and UC. METHODS We conducted a retrospective cohort study using the ImproveCareNow Network, a multicenter registry of children with inflammatory bowel disease. We included children with newly diagnosed CD and UC enrolled in ImproveCareNow Network from September 2006 to December 2018 who had at least 1 follow-up visit 12-18 months after diagnosis. Patients were stratified into normal weight, overweight, or obese categories. Primary outcome was remission at 1 year based on physician's global assessment (PGA); key secondary outcomes included short pediatric CD activity index and pediatric UC activity index. RESULTS There were 4,972 children included (70% CD). Compared with normal weight, obese and overweight children with CD did not have worse disease activity at 1 year based on PGA. However, obese children did have modestly worse disease activity based on short pediatric CD activity index (inactive 43% vs 58%, mild 48% vs 36%, and moderate-severe 9% vs 7% for obese vs normal weight, P < 0.01). For children with UC, there were no differences in disease activity at 1 year based on PGA or pediatric UC activity index. Logistic regression mirrored these findings. DISCUSSION Obese and overweight children with newly diagnosed inflammatory bowel disease do not seem to have worsened disease activity at 1 year after diagnosis compared with normal weight children.

中文翻译：

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超重和肥胖状态与新诊断的炎症性肠病儿童和青少年的疾病活动无关。

引言 尽管儿童肥胖的患病率很高，但其对克罗恩病 (CD) 和溃疡性结肠炎 (UC) 活动的影响仍未得到充分表征。本研究的目的是评估患有 CD 和 UC 的超重和肥胖儿童的疾病相关结果。方法 我们使用 ImproveCareNow 网络进行了一项回顾性队列研究，ImproveCareNow 网络是针对患有炎症性肠病的儿童进行的多中心登记。我们纳入了 2006 年 9 月至 2018 年 12 月期间加入 ImproveCareNow 网络的新诊断 CD 和 UC 儿童，他们在诊断后 12-18 个月至少进行了 1 次随访。患者被分为正常体重、超重或肥胖类别。主要结果是基于医生整体评估 (PGA) 的 1 年缓解；关键的次要结果包括小儿 CD 活动指数和小儿 UC 活动指数。结果 包括 4,972 名儿童 (70% CD)。根据 PGA，与正常体重相比，患有 CD 的肥胖和超重儿童在 1 年时没有更严重的疾病活动。然而，根据小儿科 CD 活动指数，肥胖儿童的疾病活动确实稍差（肥胖与正常体重相比，不活动 43% 对 58%，轻度 48% 对 36%，中重度 9% 对 7%，P < 0.01 ). 对于患有 UC 的儿童，根据 PGA 或儿科 UC 活动指数，1 年时的疾病活动没有差异。逻辑回归反映了这些发现。