The fundamental implications that chirality has in science and technology require continuous efforts for the development of fast, economic, and reliable quantitative methods for enantiopurity assessment. Among the different analytical approaches, chiroptical techniques in combination with supramolecular methodologies have shown promising results in terms of both costs and time analysis. In this article, a tris(2-pyridylmethyl)amines (TPMA)-based supramolecular cage is able to amplify the circular dichroism (CD) signal of a series of chiral dicarboxylic acids also in the presence of a complex mixture. This feature has been used to quantify tartaric acid in wines and to discriminate different matrixes using principal component analysis (PCA) of the raw CD data.

中文翻译：

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手性二羧酸在立体动力学超分子笼中的手性增强

手性在科学和技术中的基本意义需要不断努力开发快速、经济和可靠的对映纯度评估定量方法。在不同的分析方法中，手性光学技术与超分子方法相结合在成本和时间分析方面都显示出可喜的结果。在本文中，基于三（2-吡啶基甲基）胺 ( TPMA ) 的超分子笼能够放大一系列手性二元羧酸的圆二色性 (CD) 信号，即使存在复杂的混合物。此功能已用于量化葡萄酒中的酒石酸，并使用原始 CD 数据的主成分分析 (PCA) 来区分不同的基质。