Advancement in nanotechnology leads to the development of polysaccharides which are very efficient carriers in delivering therapeutic substances like drugs, proteins, and genes. This review describes the role of polysaccharides and their derivatives in the cellular targeting of genetic materials for the treatment of various biological disorders. Applications, challenges, advantages, and disadvantages of polysaccharides used in gene delivery are discussed in the manuscript. Cationic and natural polysaccharides are generally used for RNA and DNA delivery and exhibit better performance in gene transfection. After a substantial literature survey, it can be concluded that different polysaccharides and their derivatives are effectively used in the delivery of genetic material. Natural polysaccharides are widely used due to their advantageous properties like biocompatibility, biodegradability, and low toxicity in the biological environment.

中文翻译：

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用于生物疾病管理的遗传材料的递送：多糖及其衍生物的进展和作用

纳米技术的进步导致多糖的发展，多糖是输送药物、蛋白质和基因等治疗物质的非常有效的载体。这篇综述描述了多糖及其衍生物在遗传物质细胞靶向治疗各种生物疾病中的作用。手稿中讨论了用于基因传递的多糖的应用、挑战、优点和缺点。阳离子和天然多糖通常用于 RNA 和 DNA 递送，并在基因转染中表现出更好的性能。经过大量文献调查，可以得出结论，不同的多糖及其衍生物可有效用于遗传物质的递送。