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Progressive Application of Marine Biomaterials in Targeted Cancer Nanotherapeutics.
Current pharmaceutical design Pub Date : 2022-01-01 , DOI: 10.2174/1381612828666220422091611
Janani Indrakumar 1 , Srivarshini Sankar 1 , Harishkumar Madhyastha 2 , Gothandam Kodiveri Muthukaliannan 1
Affiliation  

The marine microenvironment harbors many unique species of organisms that produce a plethora of compounds that help mankind cure a wide range of diseases. The diversity of products from the ocean bed serves as potentially healing materials and inert vehicles carrying the drug of interest to the target site. Several composites still lay undiscovered under the blue canopy, which can provide treatment for untreated diseases that keep haunting the earth periodically. Cancer is one such disease that has been of interest to several eminent scientists worldwide due to the heterogenic complexity involved in the disease's pathophysiology. Due to extensive globalization and environmental changes, cancer has become a lifestyle disease continuously increasing exponentially in the current decade. This ailment requires a definite remedy that treats by causing minimal damage to the body's normal cells. The application of nanotechnology in medicine has opened up new avenues of research in targeted therapeutics due to their highly malleable characteristics. Marine waters contain an immense ionic environment that succors the production of distinct nanomaterials with exceptional character, yielding highly flexible molecules to modify, thus facilitating the engineering of targeted biomolecules. This review provides a short insight into an array of marine biomolecules that can be probed into cancer nanotherapeutics sparing healthy cells.

中文翻译:

海洋生物材料在靶向癌症纳米治疗中的逐步应用。

海洋微环境孕育着许多独特的生物物种,它们会产生大量化合物,帮助人类治愈多种疾病。海底产品的多样性可作为潜在的治疗材料和惰性载体,将感兴趣的药物运送到目标位置。蓝色树冠下仍有几种未被发现的复合材料,可以为周期性困扰地球的未治疗疾病提供治疗。癌症是一种这样的疾病,由于该疾病的病理生理学涉及异质性复杂性,全世界的几位著名科学家对此一直很感兴趣。由于广泛的全球化和环境变化,癌症已成为近十年来呈指数增长的生活方式疾病。这种疾病需要一种明确的治疗方法,通过对身体正常细胞造成最小的损害来治疗。纳米技术在医学中的应用由于其高度可塑性的特点,为靶向治疗的研究开辟了新的途径。海水含有巨大的离子环境,有助于生产具有特殊特性的独特纳米材料,产生高度灵活的分子进行修饰,从而促进目标生物分子的工程化。这篇综述提供了对一系列海洋生物分子的简短见解,这些生物分子可以用于探索癌症纳米治疗药物,从而保护健康细胞。海水含有巨大的离子环境,有助于生产具有特殊特性的独特纳米材料,产生高度灵活的分子进行修饰,从而促进目标生物分子的工程化。这篇综述提供了对一系列海洋生物分子的简短见解,这些生物分子可以用于探索癌症纳米治疗药物,从而保护健康细胞。海水含有巨大的离子环境,有助于生产具有特殊特性的独特纳米材料,产生高度灵活的分子进行修饰,从而促进目标生物分子的工程化。这篇综述提供了对一系列海洋生物分子的简短见解,这些生物分子可以用于探索癌症纳米治疗药物,从而保护健康细胞。
更新日期:2022-04-22
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