Hematologic malignancy outcomes have remarkably improved in the past decade with further advancement expected in future years. However, the detrimental effects of financial toxicity (FT) on patients with hematologic malignancies, because of both diagnoses and subsequent treatments, have not been studied comprehensively. We performed a systematic review of all studies reporting FT as a primary or secondary outcome among adult or pediatric patients with hematological malignancies. A total of 55 studies met the inclusion criteria for analysis. Across studies, 20–50% of patients reported some form of FT, including loss of work productivity, food and transportation costs, and depletion of savings. Younger age, lower-income level, unemployment, and rural residence were the most commonly identified risk factors for FT. Two studies looked at survival outcomes, with one reporting improvement in survival with a decrease in financial toxicity. However, significant heterogeneity in FT definitions was found between countries and payor systems. Only half of the studies (51%, n = 28) used validated survey instruments such as the COST assessment. The present systematic review identified that FT is common in patients with hematological malignancies and may be associated with poorer outcomes. However, studies of FT generally use non-standardized methods with cross-sectional analyses rather than longitudinal, prospective assessments. Further work is needed to standardize FT reporting and investigate measures to alleviate FT among patients with hematologic malignancies.

过去十年，血液恶性肿瘤的结果已显着改善，预计未来几年将进一步改善。然而，由于诊断和随后的治疗，财务毒性（FT）对血液恶性肿瘤患者的有害影响尚未得到全面研究。我们对所有报告 FT 作为成人或儿童血液恶性肿瘤患者主要或次要结局的研究进行了系统回顾。共有 55 项研究符合分析纳入标准。各项研究中，20-50% 的患者报告了某种形式的 FT，包括工作效率下降、食品和交通成本以及储蓄耗尽。年龄较小、收入水平较低、失业和农村居住是最常见的 FT 风险因素。两项研究着眼于生存结果，其中一项研究报告生存率提高，财务毒性降低。然而，不同国家和支付系统之间的 FT 定义存在显着差异。只有一半的研究（51%，n  = 28）使用了经过验证的调查工具，例如成本评估。目前的系统评价发现，FT 在血液恶性肿瘤患者中很常见，并且可能与较差的预后相关。然而，FT 研究通常使用非标准化方法进行横断面分析，而不是纵向、前瞻性评估。需要进一步开展工作来标准化 FT 报告并研究减轻血液恶性肿瘤患者 FT 的措施。