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Microrobotics for Precision Biofilm Diagnostics and Treatment
Journal of Dental Research ( IF 7.6 ) Pub Date : 2022-04-21 , DOI: 10.1177/00220345221087149
A Babeer 1, 2, 3 , M J Oh 1, 4, 5 , Z Ren 1, 4 , Y Liu 1, 6 , F Marques 2 , A Poly 7 , B Karabucak 2 , E Steager 1, 8 , H Koo 1, 4
Affiliation  

Advances in small-scale robotics and nanotechnology are providing previously unimagined opportunities for new diagnostic and therapeutic approaches with high precision, control, and efficiency. We designed microrobots for tetherless biofilm treatment and retrieval using iron oxide nanoparticles (NPs) with dual catalytic-magnetic functionality as building blocks. We show 2 distinct microrobotic platforms. The first system is formed from NPs that assemble into aggregated microswarms under magnetic fields that can be controlled to disrupt and retrieve biofilm samples for microbial analysis. The second platform is composed of 3-dimensional (3D) micromolded opacifier-infused soft helicoids with embedded catalytic-magnetic NPs that can be visualized via existing radiographic imaging techniques and controlled magnetically inside the root canal, uninterrupted by the soft and hard tissues surrounding the teeth in an ex vivo model. These microrobots placed inside the root canal can remove biofilms and be efficiently guided with microscale precision. The proof-of-concept paradigm described here can be adapted to target difficult-to-reach anatomical spaces in other natural and implanted surfaces in an automated and tether-free manner.



中文翻译:

用于精密生物膜诊断和治疗的微型机器人

小型机器人和纳米技术的进步为高精度、控制和高效的新诊断和治疗方法提供了以前无法想象的机会。我们使用具有双重催化磁性功能的氧化铁纳米颗粒(NP)作为构建块,设计了用于无绳生物膜处理和回收的微型机器人。我们展示了 2 个不同的微型机器人平台。第一个系统由纳米粒子形成,纳米粒子在磁场下组装成聚集的微群,可以控制这些微群来破坏和回收生物膜样本以进行微生物分析。第二个平台由 3 维 (3D) 微模塑注入遮光剂的软螺旋体组成,其中嵌入了催化磁性纳米粒子,可以通过现有的放射线成像技术进行可视化,并在根管内进行磁性控制,不受根管周围的软组织和硬组织的干扰。离体模型中的牙齿。这些放置在根管内的微型机器人可以去除生物膜,并以微型精度进行有效引导。这里描述的概念验证范例可以适用于以自动化和无绳方式瞄准其他自然和植入表面中难以到达的解剖空间。

更新日期:2022-04-21
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