An imbalance in the production and detoxification of reactive oxygen species and other oxidants can disrupt all types of cellular compounds, and lead to a state of oxidative stress. Preventing this state is essential to improve growth and health in animal production. Therefore, the aim of this work was to assess if the dietary supplementation of curcumin could improve the antioxidant status and intestine structure and functionality of gilthead seabream postlarvae, with the global objective of improving fish growth performance and robustness. Two experimental diets supplemented with different doses of curcumin (LOW and HIGH diets), and a commercial diet were fed to quadruplicate groups of postlarvae, for 20 days. At the end of the feeding trial fish fed the supplemented diets significantly improved their antioxidant status compared to CTRL fed fish. LOW and HIGH fed fish presented lower protein oxidative damage (P < 0.05) and higher total antioxidant capacity (P < 0.05). Moreover, postlarvae fed curcumin supplemented diets also presented an upregulation of nuclear factor erythroid 2 – related factor 2 (nrf2) and glutathione-disulfide reductase (gr) in HIGH (P < 0.05) and heat shock protein 70 (hsp70) in LOW treatments (P < 0.05). No differences were observed in growth performance, intestine morphometry, and digestive enzymes activities among treatments (P > 0.05). In conclusion, dietary curcumin supplementation was able to enhance gilthead seabream postlarvae robustness through a modulation of the oxidative status, increasing total antioxidant capacity and decreasing protein oxidative damage. This data provide evidence that curcumin can be a suitable feed additive to promote heath status and robustness of fish at early stages of development, therefore contributing for the development and sustainability of marine fish hatchery production.

活性氧和其他氧化剂的产生和解毒失衡会破坏所有类型的细胞化合物，并导致氧化应激状态。防止这种状态对于改善动物生产的生长和健康至关重要。因此，这项工作的目的是评估姜黄素的膳食补充剂是否可以改善金头鲷后期幼体的抗氧化状态以及肠道结构和功能，全球目标是提高鱼类的生长性能和健壮性。将添加不同剂量姜黄素的两种实验日粮（低和高日粮）和商业日粮分别喂给一式四份的幼体组，持续 20 天。在饲喂试验结束时，与 CTRL 饲喂的鱼相比，饲喂补充饲料的鱼显着改善了它们的抗氧化状态。低饲和高饲鱼表现出较低的蛋白质氧化损伤（P < 0.05）和较高的总抗氧化能力（P < 0.05）。此外，饲喂姜黄素补充日粮的后期幼体也表现出核因子红细胞 2 相关因子 2 的上调。nrf2 ) 和谷胱甘肽二硫化物还原酶 ( gr ) 在 HIGH (P < 0.05) 和热休克蛋白 70 ( hsp70 ) 在 LOW 处理 (P < 0.05)。各处理间生长性能、肠道形态和消化酶活性均无差异（P > 0.05）。总之，膳食姜黄素补充剂能够通过调节氧化状态、增加总抗氧化能力和减少蛋白质氧化损伤来增强金头鲷后期幼体的健壮性。这些数据提供了证据，证明姜黄素可以作为一种合适的饲料添加剂，以促进鱼类在早期发育阶段的健康状况和健壮性，从而有助于海洋鱼类孵化场生产的发展和可持续性。