Neural dynamics are shaped and constrained by the projections of a small nucleus in the pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain’s violin, activity in the LC lacks content specificity, but instead dynamically shapes the excitability and receptivity of neurons across the brain. In this review, we explain how the style of the bowing technique, which is analogous to different firing modes in the LC, affects distinct activity patterns in the rest of the brain. Through this analogical lens, we provide intuitive insights into how the complex activity of the LC acts to coordinate adaptive neural dynamics.

中文翻译：

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蓝斑在塑造适应性皮层旋律中的作用

神经动力学由脑桥中一个小核的投射形成和约束：去甲肾上腺素能蓝斑 (LC)。就像向大脑的小提琴鞠躬一样，LC 中的活动缺乏内容特异性，而是动态地塑造了整个大脑神经元的兴奋性和接受性。在这篇评论中，我们解释了类似于 LC 中不同射击模式的弓箭技巧的风格如何影响大脑其他部分的不同活动模式。通过这个类比镜头，我们提供了关于 LC 的复杂活动如何协调自适应神经动力学的直观见解。