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Antisense-mediated senseful regulation of orchestrated metabolic response
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2022-04-21 , DOI: 10.1016/j.chembiol.2022.04.002
Umut Ozcan 1
Affiliation  

Accumulation of fat in the liver predisposes affected individuals to a variety of diseases, yet the molecular mechanisms leading to steatosis still remain elusive. Matsushita et al. (2022) propose a novel mechanism that interconnects insulin resistance and fatty liver formation by an orchestrated regulation of Irs2 and its natural antisense transcript.



中文翻译:

反义介导的协调代谢反应的感知调节

肝脏中脂肪的积累使受影响的个体易患多种疾病,但导致脂肪变性的分子机制仍然难以捉摸。松下等人。(2022) 提出了一种新机制,通过对Irs2及其天然反义转录物的协调调节,将胰岛素抵抗和脂肪肝形成联系起来。

更新日期:2022-04-22
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