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Effects of ferulic acid on the growth performance, antioxidant capacity and intestinal development of piglets with intrauterine growth retardation
Journal of Animal Science ( IF 3.3 ) Pub Date : 2022-04-19 , DOI: 10.1093/jas/skac144
Jin Wan 1 , Qiong Yu 2 , Junqiu Luo 3 , Li Zhang 2 , Zheng Ruan 1, 2
Affiliation  

Neonates with intrauterine growth retardation (IUGR) are prone to suffer from delayed postnatal growth and development during the early stages of life. Ferulic acid (FA) is a phenolic compound that is abundantly present in fruits and vegetables and has various health benefits. Hence, we explored whether FA supplementation could favourably affect the growth performance, antioxidant capacity and intestinal development of piglets with IUGR. In total, eight normal-birth-weight (NBW) piglets and 16 piglets with IUGR (age, 7 days) were assigned to be fed either basic formula milk (NBW and IUGR groups, respectively) or basic formula milk supplemented with 100 mg/kg FA (IUGR + FA group) for 21 days. At necropsy, the serum and intestinal tissues were collected. FA supplementation increased (P < 0.05) the feed conversion ratio and serum total superoxide dismutase and catalase activities in piglets with IUGR. Moreover, FA supplementation elevated (P < 0.05) the duodenal lactase and maltase activities and jejunal villus height and maltase activity but reduced (P < 0.05) the duodenal crypt depth and duodenal and jejunal cell apoptosis and cleaved cysteinyl aspartic acid protease-3 (caspase-3) and cleaved caspase-9 contents in piglets with IUGR. In summary, FA supplementation could elevate antioxidant capacity and facilitate intestinal development, thus resulting in increased feed efficiency in piglets with IUGR.

中文翻译:

阿魏酸对宫内发育迟缓仔猪生长性能、抗氧化能力及肠道发育的影响

宫内发育迟缓 (IUGR) 新生儿在生命的早期阶段容易出现出生后生长发育迟缓。阿魏酸 (FA) 是一种酚类化合物,大量存在于水果和蔬菜中,具有多种健康益处。因此,我们探讨了补充 FA 是否会对 IUGR 仔猪的生长性能、抗氧化能力和肠道发育产生有利影响。总共有 8 头正常出生体重 (NBW) 仔猪和 16 头 IUGR 仔猪(7 日龄)被分配喂养基础配方奶(分别为 NBW 和 IUGR 组)或添加 100 mg/ kg FA(IUGR + FA 组)21 天。在尸检时,收集血清和肠组织。FA 补充增加 (P < 0. 05) IUGR仔猪的饲料转化率和血清总超氧化物歧化酶和过氧化氢酶活性。此外,补充 FA 提高 (P < 0.05) 十二指肠乳糖酶和麦芽糖酶活性以及空肠绒毛高度和麦芽糖酶活性,但降低 (P < 0.05) 十二指肠隐窝深度和十二指肠和空肠细胞凋亡以及裂解的半胱氨酰天冬氨酸蛋白酶-3 (caspase-3)和裂解的 caspase-9 在 IUGR 仔猪中的含量。总之,补充 FA 可以提高抗氧化能力并促进肠道发育,从而提高 IUGR 仔猪的饲料效率。05) 十二指肠乳糖酶和麦芽糖酶活性和空肠绒毛高度和麦芽糖酶活性但减少 (P < 0.05) 十二指肠隐窝深度和十二指肠和空肠细胞凋亡和裂解的半胱氨酰天冬氨酸蛋白酶-3 (caspase-3) 和裂解的 caspase- 9 IUGR仔猪的含量。总之,补充 FA 可以提高抗氧化能力并促进肠道发育,从而提高 IUGR 仔猪的饲料效率。05) 十二指肠乳糖酶和麦芽糖酶活性和空肠绒毛高度和麦芽糖酶活性但减少 (P < 0.05) 十二指肠隐窝深度和十二指肠和空肠细胞凋亡和裂解的半胱氨酰天冬氨酸蛋白酶-3 (caspase-3) 和裂解的 caspase- 9 IUGR仔猪的含量。总之,补充 FA 可以提高抗氧化能力并促进肠道发育,从而提高 IUGR 仔猪的饲料效率。
更新日期:2022-04-19
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