Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study,Journal of the National Cancer Institute

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Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study
Journal of the National Cancer Institute ( IF 10.3 ) Pub Date : 2022-04-14 , DOI: 10.1093/jnci/djac061
Daniela Mariosa ₁ , Karl Smith-Byrne ₁ , Tom G Richardson _{2,

3} , Pietro Ferrari ₄ , Marc J Gunter ₄ , Nikos Papadimitriou ₄ , Neil Murphy ₄ , Sofia Christakoudi _{5,

6} , Konstantinos K Tsilidis _{5,

7} , Elio Riboli ₅ , David Muller ₅ , Mark P Purdue ₈ , Stephen J Chanock ₈ , Rayjean J Hung _{9,

10} , Christopher I Amos ₁₁ , Tracy A O'Mara ₁₂ , Pilar Amiano _{13,

14,

15} , Fabrizio Pasanisi ₁₆ , Miguel Rodriguez-Barranco _{17,

18,

19} , Vittorio Krogh ₂₀ , Anne Tjønneland _{21,

22} , Jytte Halkjær ₂₁ , Aurora Perez-Cornago ₂₃ , María-Dolores Chirlaque _{19,

24} , Guri Skeie ₂₅ , Charlotta Rylander ₂₅ , Kristin Benjaminsen Borch ₂₅ , Dagfinn Aune _{5,

26,

27,

28} , Alicia K Heath ₅ , Heather A Ward _{5,

29} , Matthias Schulze ₃₀ , Catalina Bonet ₃₁ , Elisabete Weiderpass ₃₂ , George Davey Smith ₂ , Paul Brennan ₁ , Mattias Johansson ₁

Affiliation

International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France.
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Novo Nordisk Research Centre Oxford, Oxford, UK.
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France.
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
MRC Centre for Transplantation, King's College London, London, UK.
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain.
Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain.
Department of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
Department of Nutrition, Bjørknes University College, Oslo, Norway.
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
IQVIA, Epidemiology and Outcomes Research, Real World Solutions, IQVIA, Cambridge, MA, USA.
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
International Agency for Research on Cancer (IARC/WHO), Lyon, France.

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

中文翻译：

不同年龄的体型和六种癌症的风险：孟德尔随机化和前瞻性队列研究

目前尚不清楚生命早期的体重是否会独立于成人体重影响癌症风险。为了调查六种肥胖相关癌症的这个问题，我们使用 i) 孟德尔随机化 (MR) 分析和 ii) 前瞻性队列中的纵向分析进行了单变量和多变量分析。MR 和纵向分析均表明，10 岁时体型较大与子宫内膜癌 (ORMR=1.61, 95%CI = 1.23–2.11) 和肾癌 (ORMR=1.40, 95%CI = 1.09–1.80) 的风险较高相关. 在 MR 和队列分析中考虑成人体型后，这些关联减弱。生命早期 BMI 与其他研究的癌症并不一致。

更新日期：2022-04-14

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