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Ferroptosis in plants: regulation of lipid peroxidation and redox status.
Biochemical Journal ( IF 4.1 ) Pub Date : 2022-04-14 , DOI: 10.1042/bcj20210682
Ayelén Mariana Distéfano 1 , Gabriel Alejandro López 1 , Victoria Bauer 1 , Eduardo Zabaleta 1 , Gabriela Carolina Pagnussat 1
Affiliation  

Regulated cell death (RCD) is an essential process that plays key roles along the plant life cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD involves integrated signaling cascades and precise molecular-mediated mechanisms that are triggered in response to specific exogenous or endogenous stimuli. Ferroptosis is a cell death pathway characterized by the iron-dependent accumulation of lipid reactive oxygen species. Although first described in animals, ferroptosis in plants shares all the main core mechanisms observed for ferroptosis in other systems. In plants as in animals, oxidant and antioxidant systems outline the process of lipid peroxidation during ferroptosis. In plants, cellular compartments such as mitochondria, chloroplasts and cytosol act cooperatively and coordinately to respond to changing redox environments. This particular context makes plants a unique model to study redox status regulation and cell death. In this review, we focus on our most recent understanding of the regulation of redox state and lipid peroxidation in plants and their role during ferroptosis.

中文翻译:

植物铁死亡:脂质过氧化和氧化还原状态的调节。

调节性细胞死亡 (RCD) 是一个必不可少的过程,在植物生命周期中起着关键作用。与意外的细胞死亡不同,这是一个不受控制的生物过程,RCD 涉及集成的信号级联和精确的分子介导机制,这些机制是响应特定的外源性或内源性刺激而触发的。铁死亡是一种细胞死亡途径,其特征在于脂质活性氧物质的铁依赖性积累。虽然首次在动物中描述,植物中的铁死亡与在其他系统中观察到的铁死亡的所有主要核心机制相同。在植物和动物中,氧化剂和抗氧化系统概述了铁死亡过程中脂质过氧化的过程。在植物中,细胞区室如线粒体,叶绿体和胞质溶胶协同和协调地响应不断变化的氧化还原环境。这种特殊的背景使植物成为研究氧化还原状态调节和细胞死亡的独特模型。在这篇综述中,我们关注我们最近对植物氧化还原状态和脂质过氧化的调节及其在铁死亡过程中的作用的理解。
更新日期:2022-04-14
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