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Derivation and validation of a nomogram for predicting nonventilator hospital-acquired pneumonia among older hospitalized patients
BMC Pulmonary Medicine ( IF 3.1 ) Pub Date : 2022-04-15 , DOI: 10.1186/s12890-022-01941-z Zhihui Chen 1, 2 , Ziqin Xu 1 , Hongmei Wu 1 , Shengchun Gao 1 , Haihong Wang 1 , Jiaru Jiang 1 , Xiuyang Li 2 , Le Chen 1
BMC Pulmonary Medicine ( IF 3.1 ) Pub Date : 2022-04-15 , DOI: 10.1186/s12890-022-01941-z Zhihui Chen 1, 2 , Ziqin Xu 1 , Hongmei Wu 1 , Shengchun Gao 1 , Haihong Wang 1 , Jiaru Jiang 1 , Xiuyang Li 2 , Le Chen 1
Affiliation
Currently, there is no effective tool for predicting the risk of nonventilator hospital-acquired pneumonia (NV-HAP) in older hospitalized patients. The current study aimed to develop and validate a simple nomogram and a dynamic web-based calculator for predicting the risk of NV-HAP among older hospitalized patients. A retrospective evaluation was conducted on 15,420 consecutive older hospitalized patients admitted to a tertiary hospital in China between September 2017 and June 2020. The patients were randomly divided into training (n = 10,796) and validation (n = 4624) cohorts at a ratio of 7:3. Predictors of NV-HAP were screened using the least absolute shrinkage and selection operator method and multivariate logistic regression. The identified predictors were integrated to construct a nomogram using R software. Furthermore, the optimum cut-off value for the clinical application of the model was calculated using the Youden index. The concordance index (C-index), GiViTI calibration belts, and decision curve were analysed to validate the discrimination, calibration, and clinical utility of the model, respectively. Finally, a dynamic web-based calculator was developed to facilitate utilization of the nomogram. Predictors included in the nomogram were the Charlson comorbidity index, NRS-2002, enteral tube feeding, Barthel Index, use of sedatives, use of NSAIDs, use of inhaled steroids, and "time at risk". The C-index of the nomogram for the training and validation cohorts was 0.813 and 0.821, respectively. The 95% CI region of the GiViTI calibration belt in the training (P = 0.694) and validation (P = 0.614) cohorts did not cross the diagonal bisector line, suggesting that the prediction model had good discrimination and calibration. Furthermore, the optimal cut-off values for the training and validation cohorts were 1.58 and 1.74%, respectively. Analysis of the decision curve showed that the nomogram had good clinical value when the threshold likelihood was between 0 and 49%. The developed nomogram can be used to predict the risk of NV-HAP among older hospitalized patients. It can, therefore, help healthcare providers initiate targeted medical interventions in a timely manner for high-risk groups.
更新日期：2022-04-15
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