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Effect of chronic exposure to sertraline on social and cognitive behavior of adult male and female rats under social isolation stress
Learning and Motivation ( IF 1.488 ) Pub Date : 2022-04-14 , DOI: 10.1016/j.lmot.2022.101807
Iman Rad , Maryam Salari , Ali Dehghani , Faly Golshan , Mohammad Reza Afarinesh

The present study aimed to investigate the long-term effect of sertraline on memory, spatial learning, anxiety-like behavior, and social relationships of rats. Twenty-eight rats (14 of each sex) were isolated from their mothers between postnatal days 30 and 55 to induce social isolation (SI) stress and were then exposed either to drinking water (SI group) or sertraline (SI+Sertraline group). Fourteen rats (7 of each sex) as the control groups were housed in large Plexiglas cages (3–4 rats in each cage). Using the three-chamber social maze, elevated plus maze (EPM), and Morris water maze (MWM) tests, animal behaviors were investigated on postnatal days 61–64. Chronic exposure to SI+Sertraline decreased interaction with new rats in the novelty phase compared to SI and control rats in the social interaction test (P < 0.05). Additionally, the time spent in the closed arms of the EPM was longer in the SI+Serteraline group compared to the SI and control rats (P < 0.05). SI+Sertraline rats showed reduced distance traveled and time of movement necessary to locate the hidden platform in the MWM test compared to the SI rats during the learning phase, but memory criteria such as time spent in the trigger area in the probe test were impaired (P < 0.05). Impairments in social interaction, spatial memory, and the anxiogenic effects following chronic administration of sertraline during chronic SI may make the treatment unsuitable for people with anxiety; however, it does have benefits for learning.



中文翻译:

长期暴露于舍曲林对社会隔离应激下成年雄性和雌性大鼠社会认知行为的影响

本研究旨在调查舍曲林对大鼠记忆、空间学习、焦虑样行为和社会关系的长期影响。28 只大鼠(每种性别 14 只)在出生后第 30 天至第 55 天与它们的母亲分离,以诱导社会孤立 (SI) 压力,然后将其暴露于饮用水(SI 组)或舍曲林(SI+舍曲林组)。作为对照组的 14 只大鼠(每种性别 7 只)饲养在大型有机玻璃笼子中(每个笼子中 3-4 只大鼠)。使用三室社交迷宫、高架十字迷宫 (EPM) 和莫里斯水迷宫 (MWM) 测试,在出生后 61-64 天调查动物行为。在社交互动测试中,与 SI 和对照大鼠相比,长期暴露于 SI+舍曲林会降低新大鼠在新奇阶段与新大鼠的互动(P < 0.05)。此外,与 SI 和对照大鼠相比,SI+舍曲林组在 EPM 闭合臂中花费的时间更长(P  < 0.05)。与学习阶段的 SI 大鼠相比,SI+舍曲林大鼠在 MWM 测试中显示出定位隐藏平台所需的移动距离和移动时间减少,但记忆标准(例如在探针测试中在触发区域花费的时间)受损。P  < 0.05)。慢性 SI 期间长期服用舍曲林后社交互动、空间记忆和焦虑作用的损害可能使治疗不适合焦虑症患者;但是,它确实对学习有好处。

更新日期:2022-04-14
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