The present investigation aimed to assess the protective ability of sodium selenite and selenium nanoparticles against mercuric chloride-induced hepatotoxicity and oxidative stress in yellowfin seabream, Acanthopagrus latus. First, fish fed with sodium selenite (1 and 1.5mg/kg) and selenium nanoparticles (1 and 1.5mg/kg) for six weeks and then exposed to 80 µg/L of mercury chloride for more than two weeks. Serum levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase significantly increased and albumin serum level decreased in fish received mercury alone and those pretreated by 1.5mg/kg sodium selenite. The lipid peroxidation significantly increased and superoxide dismutase, catalase and glutathione peroxidase activities significantly decreased in liver tissue of fish received mercury alone and those pretreated by 1.5mg/kg sodium selenite. Mercury chloride exposure also resulted in tissue changes in these groups. Supplementation of sodium selenite (1mg/kg) and selenium nanoparticles (1 and 1.5mg/kg) provided acceptable protection against the toxic effects of mercury on antioxidant parameters and liver tissue structure and function. In conclusion, the results showed that mercury, even at low concentrations, is capable to induce toxic effects in A. latus and selenium pretreatment able to restore the antioxidant parameters and liver tissue structure and function in mercury-exposed fish, suggesting protective effects against mercury toxicity.

中文翻译：

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有机硒和矿物硒对黄鳍鲷幼鱼 (Acanthopagrus latus) 氯化汞诱导的氧化应激和肝组织损伤的比较影响

本研究旨在评估亚硒酸钠和硒纳米颗粒对氯化汞诱导的黄鳍鲷、棘刺鲷的肝毒性和氧化应激的保护能力。. 首先，给鱼喂食亚硒酸钠（1 和 1.5mg/kg）和硒纳米颗粒（1 和 1.5mg/kg）六周，然后暴露于 80 µg/L 氯化汞超过两周。单独接受汞和1.5mg/kg亚硒酸钠预处理的鱼血清碱性磷酸酶、丙氨酸氨基转移酶、天冬氨酸氨基转移酶水平显着升高，而白蛋白血清水平降低。单独接受汞和1.5mg/kg亚硒酸钠预处理的鱼肝组织脂质过氧化显着增加，超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性显着降低。氯化汞暴露也导致这些组的组织变化。亚硒酸钠 (1mg/kg) 和硒纳米粒子 (1 和 1. 5mg/kg）对汞对抗氧化参数和肝组织结构和功能的毒性作用提供了可接受的保护。总之，结果表明，即使是低浓度的汞，也能够在人体中引起毒性作用。一个。latus和硒预处理能够恢复汞暴露鱼类的抗氧化参数和肝组织结构和功能，表明对汞毒性具有保护作用。