Background. Hypertension as a major risk factor for cardiovascular diseases is among the leading causes of death worldwide. The relationship between elevated serum levels of liver enzymes and hypertension has been reported in limited studies, and to the best of our knowledge, there are no previous reports in the literature on this issue in the southeast of Iran. Our investigation aimed at evaluating the relation between ALT, AST, GGT, and ALP with hypertension in the Rafsanjan Cohort Study, a city in Kerman Province, Iran. Methods. In this cross-sectional study, we used data obtained from the Rafsanjan Cohort Study (RCS), as a part of the prospective epidemiological research studies in Iran (PERSIAN). The association of the liver enzymes levels with hypertension was investigated using the multivariable logistic regression models. Results. Among 9930 participants, the mean age (±SD) was 49.94 (±9.56) years, and 46.56% were men. The odds of abnormal blood pressure significantly increased along with the higher levels of ALT, GGT, and ALP which remained significant only for ALP after adjustment for all confounding variables in both males and females (OR in males: 1.36, 95% CI = 1.09–1.69, OR in females: 1.25, 95% CI = 1.01–1.54). In subjects with normal levels of ALT, AST, GGT, and ALP, dose-response increases were observed for abnormal blood pressure in both genders. Finally, we found that, among liver enzymes, only elevated ALP was significantly correlated with the odds of stage 1 hypertension and stage 2 hypertension for both genders. Conclusions. In subjects with normal levels of ALT, AST, GGT, and ALP, dose-response increases were observed for abnormal blood pressure in both genders. Increased serum ALP activity was positively associated with increased odds of hypertension in males and females. Therefore, increased ALP could be an early indicator of hypertension.

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评估血清肝酶与高血压之间的关系：基于 Rafsanjan 队列研究数据的横断面研究

背景。高血压是心血管疾病的主要危险因素，是全球主要的死亡原因之一。有限的研究报道了血清肝酶水平升高与高血压之间的关系，据我们所知，伊朗东南部的文献中没有关于此问题的先前报道。我们的调查旨在评估伊朗克尔曼省城市 Rafsanjan 队列研究中 ALT、AST、GGT 和 ALP 与高血压的关系。方法. 在这项横断面研究中，我们使用了从 Rafsanjan 队列研究 (RCS) 获得的数据，作为伊朗前瞻性流行病学研究 (PERSIAN) 的一部分。使用多变量逻辑回归模型研究肝酶水平与高血压的关系。结果. 在 9930 名参与者中，平均年龄 (±SD) 为 49.94 (±9.56) 岁，其中男性占 46.56%。血压异常的几率随着 ALT、GGT 和 ALP 水平的升高而显着增加，在调整男性和女性的所有混杂变量后，仅 ALP 仍然显着（男性 OR：1.36，95% CI = 1.09– 1.69，或女性：1.25, 95% CI = 1.01–1.54)。在 ALT、AST、GGT 和 ALP 水平正常的受试者中，观察到两性血压异常的剂量反应增加。最后，我们发现，在肝酶中，只有升高的 ALP 与男女患 1 期高血压和 2 期高血压的几率显着相关。结论. 在 ALT、AST、GGT 和 ALP 水平正常的受试者中，观察到两性血压异常的剂量反应增加。血清 ALP 活性的增加与男性和女性患高血压的几率增加呈正相关。因此，ALP 升高可能是高血压的早期指标。