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Why novel mRNA modifications are so challenging and what we can do about it
Nature Reviews Molecular Cell Biology ( IF 112.7 ) Pub Date : 2022-04-14 , DOI: 10.1038/s41580-022-00485-8
Audrey Penning 1 , Jana Jeschke 1 , François Fuks 1
Affiliation  

The discovery of diverse chemical modifications of mRNA has spurred efforts to identify, map and characterize them. Yet aside from N6-methyladenosine (m6A), progress in epitranscriptomics has been stymied by discrepant data. Here we discuss the main obstacles in studying novel mRNA modifications and offer insights into how to surmount them. Progress in the characterization of new mRNA modifications has been slow. Fuks and colleagues explain why and offer potential solutions.

中文翻译:

为什么新的 mRNA 修饰如此具有挑战性以及我们能做些什么

对 mRNA 的多种化学修饰的发现促使人们努力识别、绘制和表征它们。然而,除了 N6-甲基腺苷 (m6A) 之外,表观转录组学的进展一直受到不一致数据的阻碍。在这里,我们讨论了研究新型 mRNA 修饰的主要障碍,并提供了如何克服这些障碍的见解。新 mRNA 修饰的表征进展缓慢。Fuks 及其同事解释了原因并提供了潜在的解决方案。
更新日期:2022-04-14
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