当前位置: X-MOL 学术Fetal Pediatr. Pathol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Severe Adams-Oliver Syndrome after Maternal COVID-19 Infection Could Be Another Effect of the SARS-CoV-2 Inflammatory Storm? Case Report
Fetal and Pediatric Pathology ( IF 1.1 ) Pub Date : 2022-04-12 , DOI: 10.1080/15513815.2022.2064018
Marcos Masaru Okido 1 , Conrado Savio Ragazini 1 , Geraldo Duarte 1 , Conrado Milani Coutinho 1 , Alessandra Cristina Marcolin 1
Affiliation  

Abstract

Background. Adams-Oliver syndrome is a congenital disease whose main findings are aplasia cutis congenita of the scalp and terminal transverse limb defects. The pathogenesis is unknown, but it is postulated that ischemic events in susceptible tissues cause the lesions in the embryonic period.

Case report. We present a newborn with a severe phenotype of Adams-Oliver syndrome. The infant’s mother had a SARS-CoV-2 infection in the first trimester of pregnancy. Prenatal ultrasound indicates a probable worsening of the disease after the first trimester.

Conclusion. This study shows a previously unpublished severe AOS phenotype in a term newborn. There are some signs that the disease could have progressed beyond the first trimester, either spontaneously or by the inflammatory mechanisms of SARS-CoV-2.



中文翻译:

母亲感染 COVID-19 后出现的严重亚当斯-奥利弗综合症可能是 SARS-CoV-2 炎症风暴的另一个影响?案例报告

摘要

背景。Adams-Oliver 综合征是一种先天性疾病,其主要表现为头皮先天性皮肤发育不全和四肢末端横断性缺损发病机制尚不清楚,但据推测,易感组织的缺血事件会导致胚胎期的病变。

病例报告。我们介绍了一个具有严重亚当斯-奥利弗综合征表型的新生儿。婴儿的母亲在怀孕的前三个月感染了 SARS-CoV-2。产前超声表明疾病可能在妊娠早期恶化。

结论。这项研究显示了一个足月新生儿以前未发表的严重 AOS 表型。有一些迹象表明,该疾病可能自发地或通过 SARS-CoV-2 的炎症机制在早孕期之后进展。

更新日期:2022-04-12
down
wechat
bug