Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo et al. identify RIPK1 as an interferon-stimulated gene with potent effects on cell extrinsic and intrinsic immunotherapy resistance.

中文翻译：

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RIP(K)消除免疫治疗耐药性

干扰素信号介导对免疫检查点阻断疗法的抵抗，但其潜在机制尚不清楚。在本期《免疫》中，Cucolo 等人。确定RIPK1是一种干扰素刺激基因，对细胞外在和内在免疫治疗耐药性具有有效影响。