Immune checkpoint blockade has dramatically improved cancer therapy but remains ineffective for most colorectal tumors. In this issue of Immunity, Peuker et al. describe a microbiota-myeloid-tumor cell crosstalk that inhibits CD8⁺ T cells and promotes colorectal cancer progression.

中文翻译：

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微生物-骨髓-肿瘤：对抗 T 细胞的结肠三联征

免疫检查点阻断显着改善了癌症治疗，但对大多数结直肠肿瘤仍然无效。在本期Immunity中，Peuker 等人。描述了一种抑制 CD8 ⁺ T 细胞并促进结直肠癌进展的微生物群-骨髓-肿瘤细胞串扰。