Abstract

The corpus callosum (CC) is involved in several cognitive processes and the interhemispheric transfer of information. The current case study investigated neurocognitive and emotional processes in a 7-year-old female with partial agenesis of the corpus callosum, with an absent splenium and posterior body, with comorbid autism and ADHD. We measured cognitive functions, such as response inhibition, error monitoring, attentional disengagement, and attention capture by irrelevant emotional stimuli. We found that response inhibition was intact in the case. When happy faces were used as stop-signals, it interfered with response inhibition compared to angry-face–stop-signals. Similarly, happy faces (relative to angry faces) interfered with error monitoring; irrelevant angry faces captured attention more than happy faces. Attentional disengagement functions were impaired in the case compared to healthy controls. The findings give an insight into the interaction between cognition and emotion in pediatric partial agenesis of the CC, and have important clinical and theoretical implications.

摘要

胼胝体 (CC) 参与多个认知过程和半球间信息传递。当前的案例研究调查了一名 7 岁女性的神经认知和情绪过程，该女性患有部分胼胝体发育不全，压部和后体缺失，伴有自闭症和多动症。我们测量了认知功能，例如反应抑制、错误监控、注意力脱离和不相关情绪刺激引起的注意力捕获。我们发现在这种情况下反应抑制是完整的。当笑脸被用作停止信号时，与愤怒的脸停止信号相比，它会干扰反应抑制。同样，笑脸（相对于生气脸）会干扰错误监控；无关紧要的愤怒面孔比快乐的面孔更能吸引注意力。与健康对照组相比，该病例的注意力脱离功能受损。这些发现深入了解了儿童 CC 部分发育不全中认知和情绪之间的相互作用，并具有重要的临床和理论意义。