Interferon activated gene 204 protects against bone loss in experimental periodontitis,Journal of Periodontology

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Interferon activated gene 204 protects against bone loss in experimental periodontitis
Journal of Periodontology ( IF 4.3 ) Pub Date : 2022-04-11 , DOI: 10.1002/jper.21-0668
Karen V Swanson ₁ , Mustafa Girnary ₂ , Tomaz Alves ₃ , Jenny Py Ting _{4,

5,

6} , Kimon Divaris ₇ , Jim Beck ₃ , Carolina Maschietto Pucinelli ₈ , Raquel Assed Bezerra da Silva ₈ , Dilek Uyan ₃ , Justin E Wilson ₉ , William T Seaman ₁₀ , Jennifer Webster-Cyriaque ₁₀ , Nishma Vias ₂ , Yizu Jiao ₂ , Lloyd Cantley ₁₁ , Arnaud Marlier ₁₂ , Roland R Arnold ₁₃ , Julie T Marchesan ₃

Affiliation

Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Curriculum in Doctor of Dental Surgery, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Division of Comprehensive Oral Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Immunobiology, College of Medicine, The University of Arizona, Tucson, Arizona, USA.
Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.
Division of Diagnostic Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Periodontal destruction can be the result of different known and yet-to-be-discovered biological pathways. Recent human genetic association studies have implicated interferon-gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) with high periodontal interleukin (IL)-1β levels and more destructive disease, but mechanistic evidence is lacking. Here, we sought to experimentally validate these observational associations and better understand IFI16 and AIM2's roles in periodontitis.

中文翻译：

干扰素激活基因204可防止实验性牙周炎中的骨质流失

牙周破坏可能是不同的已知和尚未发现的生物途径的结果。最近的人类遗传关联研究表明，干扰素-γ诱导蛋白 16 ( IFI16 ) 在黑色素瘤 2 ( AIM2 )中缺失，且牙周白细胞介素 (IL)-1β 水平较高且更具破坏性，但缺乏机制证据。在这里，我们试图通过实验验证这些观察到的关联，并更好地了解 IFI16 和 AIM2 在牙周炎中的作用。

更新日期：2022-04-11

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