Journal of Orthopaedic Translation ( IF 6.6 ) Pub Date : 2022-04-08 , DOI: 10.1016/j.jot.2022.03.002 Qian Liu 1 , Qi Tang 1 , Lele Liao 1 , Ding Li 1 , Weihong Zhu 1 , Chunfeng Zhao 2
Chronic rotator cuff tears are debilitating diseases which significantly affect patients’ quality of life and pose substantial financial burden to the society. The intraoperative reparability of injured tendon and postoperative probability of tendon retear are highly associated with the quality of torn muscles, specifically, the severity of muscle atrophy and fatty infiltration. Animal models that reproduce the characteristic muscle pathology after rotator cuff injury have been developed and used to provide insight into the underlying biology and pathophysiology. In this review, we briefly summarize the current information obtained from preclinical animal studies regarding the degenerative change of cuff muscle subsequent to tendon release and/or suprascapular nerve denervation. Importantly, we focus on the potential translational therapeutic targets or agents for the prevention or reversal of muscle atrophy and fatty infiltration. While further studies are warranted to assess the safety and efficacy of novel therapies derived from these preclinical animal research, we believe that their clinical translation for the treatment of rotator cuff disorders is on the horizon.
The Translational potential of this article
Novel therapeutic strategies described in this review from preclinical animal studies hold a great translational potential for preventing or reversing rotator cuff muscle pathology, while further assessments on their safety and efficacy are warranted.
中文翻译:
临床前动物模型对肩袖损伤后肌肉退化的转化疗法
慢性肩袖撕裂是一种使人衰弱的疾病,严重影响患者的生活质量,并给社会带来巨大的经济负担。损伤肌腱的术中可修复性和术后肌腱再撕裂的可能性与撕裂肌肉的质量高度相关,特别是肌肉萎缩和脂肪浸润的严重程度。已经开发出能够在肩袖损伤后再现特征性肌肉病理学的动物模型,并用于提供对潜在生物学和病理生理学的深入了解。在这篇综述中,我们简要总结了从临床前动物研究中获得的关于肌腱释放和/或肩胛上神经去神经支配后袖带肌肉退行性变化的当前信息。重要的,我们专注于预防或逆转肌肉萎缩和脂肪浸润的潜在转化治疗靶点或药物。虽然需要进一步的研究来评估源自这些临床前动物研究的新疗法的安全性和有效性,但我们相信它们用于治疗肩袖疾病的临床转化即将到来。
本文的转化潜力
本综述中描述的临床前动物研究中描述的新治疗策略在预防或逆转肩袖肌肉病理方面具有巨大的转化潜力,同时有必要对其安全性和有效性进行进一步评估。