ABSTRACT

Diabetic neuropathy in children and adolescents with Type 1 diabetes mellitus is rare and is usually subclinical and a complication of the late diabetes period. A 17-year-old boy admitted with a right foot drop of sudden onset was diagnosed with peroneal nerve palsy. He had had osmotic polyuria, polydipsia and weight loss for the past 2 months; his blood glucose was 25 mmol/L (<7.8), HbA1c 15.2% (4.0–5.6) and vitamin B₁₂ 125 pg/ml (180–914). The peroneal nerve palsy resolved within 3 months with blood glucose regulation and B₁₂ supplementation. Diabetes should be borne in mind in the differential diagnosis of unusual cases of mononeuropathy.

Abbreviations: DCCTS: Diabetes Control and Complications Trial Study; DM: diabetes mellitus; DN: diabetic neuropathy; GAD: glutamic acid decarboxylase; PN: peripheral neuropathy; T1DM: Type 1 diabetes mellitus.

摘要

患有 1 型糖尿病的儿童和青少年的糖尿病神经病变很少见，通常是亚临床的，是糖尿病晚期的并发症。一名 17 岁男孩因右脚突然下垂入院，被诊断为腓神经麻痹。近2个月有渗透性多尿、烦渴、体重减轻；他的血糖为 25 mmol/L (<7.8)，HbA1c 为 15.2% (4.0–5.6)，维生素 B 为₁₂ 125 pg/ml (180–914)。通过血糖调节和 B ₁₂补充，腓神经麻痹在 3 个月内得到缓解。在对不寻常的单神经病病例进行鉴别诊断时，应牢记糖尿病。

缩写：DCCTS：糖尿病控制和并发症试验研究；DM：糖尿病；DN：糖尿病性神经病变；GAD：谷氨酸脱羧酶；PN：周围神经病变；T1DM：1 型糖尿病。