Extracellular vesicles (EVs) and their cargo act as signaling moieties by transferring their cargo to recipient cells, thereby mediating intercellular communication in complex tissue environments such as the tumor microenvironment. In the accompanying paper, Kudo et al. describe the interaction between tumor EVs and soluble phospholipase released by macrophages, leading to the remodeling of EV membranes and the release of lipid mediators that facilitate tumor growth by inducing an immune-tolerant phenotype.

中文翻译：

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飞溅：不断扩大的 EV 信号库

细胞外囊泡 (EV) 及其货物通过将其货物转移到受体细胞来充当信号部分，从而介导复杂组织环境（如肿瘤微环境）中的细胞间通讯。在随附的论文中，Kudo 等人。描述了肿瘤EV与巨噬细胞释放的可溶性磷脂酶之间的相互作用，导致EV膜的重塑和脂质介质的释放，这些介质通过诱导免疫耐受表型促进肿瘤生长。