In a recent paper in EMBO Molecular Medicine, Weis et al. reveal that cardiac endothelial cells can oxidize ketone bodies, which enhances cell proliferation, migration, and vessel sprouting. Furthermore, increasing ketone body levels with a ketogenic diet can increase endothelial cell proliferation and prevent blood vessel rarefication in hypertrophied mouse hearts. This suggests that increasing endothelial cell ketone oxidation has potential in treating heart failure.

中文翻译：

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酮调节内皮稳态

在最近发表于EMBO Molecular Medicine的一篇论文中，Weis 等人。揭示心脏内皮细胞可以氧化酮体，从而增强细胞增殖、迁移和血管发芽。此外，通过生酮饮食增加酮体水平可以增加内皮细胞增殖并防止肥大小鼠心脏中的血管稀疏。这表明增加内皮细胞酮氧化具有治疗心力衰竭的潜力。