The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro BBB models. In this article, we describe the astrocyte roles in the BBB functioning and human in vitro BBB models.

中文翻译：

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星形胶质细胞和人类人工血脑屏障模型。

血脑屏障 (BBB) 作为内皮细胞的高度选择性边界，通过选择性控制包括免疫系统成分在内的细胞和分子的进入，保护中枢神经系统免受潜在有害物质的侵害。为了研究 BBB 特性、寻找合适的治疗方法并确定新的药物靶点，需要开发具有代表性的体外 BBB 模型。在本文中，我们描述了星形胶质细胞在 BBB 功能和人体体外 BBB 模型中的作用。