Treatment for delayed wound healing resulting from peripheral vascular diseases and diabetic foot ulcers remains a challenge. A novel surgical technique named 'tibial cortex transverse transport' (TTT) has been developed for treating peripheral ischaemia, with encouraging clinical effects. However, its underlying mechanisms remain unclear. In the present study, we explored the potential biological mechanisms of TTT surgery using various techniques in a rat TTT animal model.

中文翻译：

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胫骨皮质横向运输通过增强血管生成和免疫调节加速伤口愈合。

外周血管疾病和糖尿病足溃疡导致的伤口愈合延迟的治疗仍然是一个挑战。一种名为“胫骨皮质横向转运”（TTT）的新型手术技术已被开发用于治疗外周缺血，具有令人鼓舞的临床效果。然而，其潜在机制仍不清楚。在本研究中，我们在大鼠 TTT 动物模型中使用各种技术探索了 TTT 手术的潜在生物学机制。