Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

用于模拟周围神经的植入式生物电子设备可用于治疗对传统药物疗法有抵抗力的疾病。然而，对于许多神经目标，这需要侵入性手术和植入笨重的设备（至少在一个维度上大约几厘米）。在这里，我们报告了血管内无线和无电池毫米植入物的设计和体内概念验证测试，用于刺激传统手术难以触及的特定周围神经。该设备可以通过经皮导管输送，并利用磁电材料通过数字可编程 1 mm × 0.8 mm 片上系统通过组织接收数据和电力。将该装置直接植入大鼠的坐骨神经顶部和猪的股动脉附近（通过导管将刺激导线引入血管），可以对动物的坐骨神经和股神经进行无线刺激。微创磁电植入物可以刺激神经，而无需进行开放手术或植入电池供电的脉冲发生器。