Objective: To describe focal epilepsy in patients with Laron syndrome (LS). Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time four patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus (SE). EEGs in all four patients showed interictal epileptiform discharges (IEDs) in the temporal regions. Three achieved long-term seizure freedom on anti-seizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, that seems to be unrelated to hypoglycemic episodes in childhood.


中文翻译：

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拉伦综合征患者的局灶性癫痫

目的：描述 Laron 综合征 (LS) 患者的局灶性癫痫。方法：数据来自 75 名 LS 患者的单中心队列的医疗记录。结果：我们首次描述了四名同时患有局灶性癫痫和 LS 的患者。其中两人经历了癫痫持续状态 (SE) 发作。所有四名患者的脑电图均在颞​​区显示发作间期癫痫样放电 (IED)。三人在使用抗癫痫药物时实现了长期无癫痫发作。结论：LS 患者可能有发生局灶性癫痫的风险，这似乎与儿童期的低血糖发作无关。