The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.

中文翻译：

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垂死细胞衍生的 SAM 会关闭炎症

巨噬细胞清除垂死细胞会释放关闭炎症的介质。Ampomah 等人。揭示了源自凋亡货物的氨基酸如何改变巨噬细胞的甲基化表观基因组，从而阻止终止炎症反应的 ERK 依赖性通路。