当前位置: X-MOL 学术Nat. Rev. Clin. Oncol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Clinical relevance of tumour-associated macrophages
Nature Reviews Clinical Oncology ( IF 78.8 ) Pub Date : 2022-03-30 , DOI: 10.1038/s41571-022-00620-6
Mikael J Pittet 1, 2, 3, 4, 5, 6 , Olivier Michielin 3, 6, 7 , Denis Migliorini 3, 4, 5, 6
Affiliation  

In the past decade, substantial advances have been made in understanding the biology of tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A particular aspect that is becoming increasingly clear is that the interaction of TAMs with cancer cells and stromal cells in the tumour microenvironment enables and sustains most of the hallmarks of cancer. Therefore, manipulation of TAMs could enable improved disease control in a substantial fraction of patients across a large number of cancer types. In this Review, we examine the diversity of TAMs in various cancer indications and how this heterogeneity is being revisited with the advent of single-cell technologies, and then explore the current knowledge on the functional roles of different TAM states and the prognostic and predictive value of TAM-related signatures. We also review agents targeting TAMs that are currently being or will soon be tested in clinical trials, and how manipulations of TAMs can improve existing anticancer treatments. Finally, we discuss how TAM-targeting approaches could be further integrated into routine clinical practice, considering a precision oncology approach and viewing TAMs as a dynamic population that can evolve under treatment pressure.



中文翻译:

肿瘤相关巨噬细胞的临床相关性

在过去十年中,在了解肿瘤相关巨噬细胞 (TAM) 的生物学方面取得了重大进展,并且它们的临床相关性正在显现。越来越清楚的一个特定方面是,TAM 与肿瘤微环境中的癌细胞和基质细胞的相互作用能够实现并维持癌症的大部分特征。因此,对 TAM 的操作可以改善大量癌症类型中相当一部分患者的疾病控制。在这篇综述中,我们研究了 TAM 在各种癌症适应症中的多样性,以及随着单细胞技术的出现如何重新审视这种异质性,然后探索关于不同 TAM 状态的功能作用及其预后和预测价值的当前知识与 TAM 相关的签名。我们还审查了目前正在或即将在临床试验中测试的靶向 TAM 的药物,以及 TAM 的操作如何改善现有的抗癌治疗。最后,我们讨论了如何将 TAM 靶向方法进一步整合到常规临床实践中,考虑精确的肿瘤学方法并将 TAM 视为可以在治疗压力下进化的动态群体。

更新日期:2022-03-30
down
wechat
bug