BACKGROUND AND HYPOTHESIS Facial Emotion Recognition is a key domain of social cognition associated with psychotic disorders as a candidate intermediate phenotype. In this study, we set out to investigate global and specific facial emotion recognition deficits in first-episode psychosis, and whether polygenic liability to psychotic disorders is associated with facial emotion recognition. STUDY DESIGN 828 First Episode Psychosis (FEP) patients and 1308 population-based controls completed assessments of the Degraded Facial Affect Recognition Task (DFAR) and a subsample of 524 FEP and 899 controls provided blood or saliva samples from which we extracted DNA, performed genotyping and computed polygenic risk scores for schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MD). STUDY RESULTS A worse ability to globally recognize facial emotion expressions was found in patients compared with controls [B= -1.5 (0.6), 95% CI -2.7 to -0.3], with evidence for stronger effects on negative emotions (fear [B = -3.3 (1.1), 95% CI -5.3 to -1.2] and anger [B = -2.3 (1.1), 95% CI -4.6 to -0.1]) than on happiness [B = 0.3 (0.7), 95% CI -1 to 1.7]. Pooling all participants, and controlling for confounds including case/control status, facial anger recognition was associated significantly with Schizophrenia Polygenic Risk Score (SZ PRS) [B = -3.5 (1.7), 95% CI -6.9 to -0.2]. CONCLUSIONS Psychosis is associated with impaired recognition of fear and anger, and higher SZ PRS is associated with worse facial anger recognition. Our findings provide evidence that facial emotion recognition of anger might play a role as an intermediate phenotype for psychosis.

中文翻译：

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精神病中的面部情绪识别以及与精神分裂症多基因风险的关联：来自多中心 EU-GEI 病例对照研究的结果。

背景和假设面部情绪识别是与作为候选中间表型的精神病相关的社会认知的关键领域。在这项研究中，我们着手调查首发精神病中的全局和特定面部情绪识别缺陷，以及对精神疾病的多基因易感性是否与面部情绪识别有关。研究设计 828 名首发精神病 (FEP) 患者和 1308 名基于人群的对照完成了对退化面部情感识别任务 (DFAR) 的评估，524 名 FEP 和 899 名对照的子样本提供了血液或唾液样本，我们从中提取 DNA，进行基因分型并计算精神分裂症 (SZ)、双相情感障碍 (BD) 和重度抑郁症 (MD) 的多基因风险评分。研究结果 与对照组相比，患者整体识别面部情绪表情的能力较差 [B= -1.5 (0.6)，95% CI -2.7 至 -0.3]，有证据表明对负面情绪的影响更强（恐惧 [B = -3.3 (1.1), 95% CI -5.3 to -1.2] 和愤怒 [B = -2.3 (1.1), 95% CI -4.6 to -0.1]) 比幸福感 [B = 0.3 (0.7), 95% CI -1 到 1.7]。汇集所有参与者，并控制包括病例/对照状态在内的混杂因素，面部愤怒识别与精神分裂症多基因风险评分 (SZ PRS) 显着相关 [B = -3.5 (1.7)，95% CI -6.9 至 -0.2]。结论 精神病与对恐惧和愤怒的识别能力受损有关，较高的 SZ PRS 与较差的面部愤怒识别能力有关。