North, Benbarche et al. engineered synthetic introns that were spliced specifically in cancer cells expressing the mutant spliceosome factor SF3B1. This led to expression of herpes simplex virus-thymidine kinase and vulnerability of cancer cells to treatment with the antiviral drug ganciclovir.

中文翻译：

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靶向剪接体突变细胞的特洛伊木马

北，Benbarche 等人。工程合成内含子在表达突变剪接体因子 SF3B1 的癌细胞中特异性剪接。这导致单纯疱疹病毒胸苷激酶的表达和癌细胞对抗病毒药物更昔洛韦治疗的脆弱性。