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Eliciting neural mechanisms of music medicine for epilepsy
Interdisciplinary Science Reviews ( IF 1.1 ) Pub Date : 2022-03-24 , DOI: 10.1080/03080188.2022.2036520
Michael A. Casey 1, 2 , Robert Quon 3, 4 , Barbara C. Jobst 3, 4
Affiliation  

ABSTRACT

Prior research involving persons with drug-resistant epilepsy has demonstrated that listening to some music decreases the probability of clinical seizures and their related comorbidities. This article reviews recent research designed to elicit the neural mechanisms behind positive outcomes on biomarkers of the disease. Using novel music analytical and neurophysiological experimental methods, our results showed positive effects on epilepsy using 15-second gamma-band (40-Hz) complex tones as well as Mozart's Sonata for Two Pianos in D Major (K448). We also observed greater effects with increased stimulus duration. Further analysis elicited effects localized to bilateral frontal brain regions due to transitions between musical phrases. Finally, music matched for patient preference from a range of musical styles was not as effective as 40-Hz tones or Mozart's K448. Understanding these results required expertise in both music and neuroscience, and could yield reliable music-based interventions for epilepsy that may also be transferable to other brain disorders.



中文翻译:

癫痫音乐医学的神经机制探究

摘要

先前涉及耐药性癫痫患者的研究表明,听一些音乐可以降低临床癫痫发作及其相关合并症的可能性。本文回顾了最近旨在引出疾病生物标志物积极结果背后的神经机制的研究。使用新颖的音乐分析和神经生理学实验方法,我们的结果显示使用 15 秒伽马波段 (40-Hz) 复杂音调以及莫扎特的 D 大调两首钢琴奏鸣曲 (K448) 对癫痫有积极影响。我们还观察到刺激持续时间增加的效果更大。由于乐句之间的转换,进一步的分析引发了局限于双侧额脑区域的影响。最后,从一系列音乐风格中匹配患者偏好的音乐不如 40-Hz 音调或莫扎特的 K448 有效。了解这些结果需要音乐和神经科学方面的专业知识,并且可以产生可靠的基于音乐的癫痫干预措施,也可能转移到其他脑部疾病。

更新日期:2022-03-24
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