The mechanistic contribution of cerebrovascular dysfunction to neurodegenerative diseases is difficult to determine. New single-cell transcriptomic analyses of human brain microvessels have identified transcriptomic signatures along the arteriovenous axis and transcriptional changes in the cerebrovasculature in Alzheimer disease and Huntington disease. This approach could advance our understanding of brain health and disease.

中文翻译：

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人类脑血管系统的转录组图

脑血管功能障碍对神经退行性疾病的机制贡献难以确定。新的人脑微血管单细胞转录组分析已经确定了阿尔茨海默病和亨廷顿病中沿动静脉轴的转录组特征和脑血管系统的转录变化。这种方法可以促进我们对大脑健康和疾病的理解。