A Polyphenol-Rich Diet Increases the Gut Microbiota Metabolite Indole 3-Propionic Acid in Older Adults with Preserved Kidney Function,Molecular Nutrition & Food Research

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A Polyphenol-Rich Diet Increases the Gut Microbiota Metabolite Indole 3-Propionic Acid in Older Adults with Preserved Kidney Function
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2022-03-22 , DOI: 10.1002/mnfr.202100349
Gregorio Peron _{1,

2} , Tomás Meroño _{1,

2} , Giorgio Gargari ₃ , Nicole Hidalgo-Liberona _{1,

2} , Antonio Miñarro _{2,

4} , Esteban Vegas Lozano _{2,

4} , Pol Castellano-Escuder _{1,

2,

4} , Raúl González-Domínguez _{1,

2} , Cristian Del Bo' ₃ , Stefano Bernardi ₃ , Paul A Kroon ₅ , Antonio Cherubini ₆ , Patrizia Riso ₃ , Simone Guglielmetti ₃ , Cristina Andrés-Lacueva _{1,

2}

Affiliation

Dietary polyphenols can alter the gut microbiota (GM) and promote the production of bioactive metabolites. Several indoles result of GM metabolism of dietary tryptophan have been associated with intestinal barrier integrity. Our aim is to study the changes in GM-derived indoles during a polyphenol-rich (PR) diet intervention in older adults.

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