An exhaustive search of the world's literature was performed to analyze all case reports and series on the modified osteo-odonto-keratoprosthesis (MOOKP) published up to January 2022. The demographic profile, the primary indication for surgery, surgical technique variations, postoperative medical management, long-term functional and anatomical outcomes, and intra- and postoperative complications were analyzed and compared. Additionally, some of the authors' (GI, VP, and GA) unpublished MOOKP cases were studied. An extensive literature search yielded 37 case series and case reports. Overall, 958 patients were analyzed. The most common indication for surgery was autoimmune disease (39.1%), closely followed by chemical injury (38.8%). The most common intraoperative complications (21.67%) included maxillofacial, vitreous hemorrhage/vitritis, and mucosal. The most common postoperative complications (78.4%) were lamina and oral mucosa-associated, secondary glaucoma, and choroid/retinal detachment. Follow-up periods ranged from one to 364 months (median: 36.7 months). Altogether, 78% of patients achieved a visual acuity of 20/400 or better at the end of the follow-up period, and 91.2% improved at least temporarily after MOOKP surgery. Mean anatomic success at the end-of-follow-up for all patients was 88.25% (range, 50–100%). The long-term anatomic and functional success of the MOOKP makes it a reliable option for visual rehabilitation in patients with bilateral corneal blindness and end-stage ocular surface disease. This review aims to describe the evolution of the MOOKP procedure, analyzing all published case series for its long-term reliability, visual and anatomical outcomes, complications, and future directions.

对世界文献进行了详尽的检索，以分析截至 2022 年 1 月发表的关于改良骨-牙-角膜移植 (MOOKP) 的所有病例报告和系列。人口统计资料、手术的主要适应症、手术技术变化、术后医疗管理、长期功能和解剖结果，以及术中和术后并发症进行了分析和比较。此外，还研究了一些作者（GI、VP 和 GA）未发表的 MOOKP 案例。广泛的文献检索产生了 37 个病例系列和病例报告。总共分析了 958 名患者。最常见的手术指征是自身免疫性疾病（39.1%），紧随其后的是化学损伤（38.8%）。最常见的术中并发症（21.67%）包括颌面部、玻璃体出血/玻璃体炎、和粘膜。最常见的术后并发症（78.4%）是椎板和口腔黏膜相关的继发性青光眼和脉络膜/视网膜脱离。随访期从 1 个月到 364 个月不等（中位数：36.7 个月）。总共有 78% 的患者在随访期结束时视力达到 20/400 或更好，91.2% 的患者在 MOOKP 手术后至少暂时改善。所有患者在随访结束时的平均解剖成功率为 88.25%（范围为 50-100%）。MOOKP 的长期解剖和功能成功使其成为双侧角膜失明和终末期眼表疾病患者视觉康复的可靠选择。本综述旨在描述 MOOKP 程序的演变，分析所有已发表的病例系列的长期可靠性、视觉和解剖结果，