SARS-CoV-2 infection poses increased risks of poor outcomes during pregnancy, including preterm birth and stillbirth. There is also developing concern over the effects of SARS-CoV-2 infection on the placenta, and these effects seem to vary between different viral variants. Despite these risks, many pregnant individuals have been reluctant to be vaccinated against the virus owing to safety concerns. We now have extensive data confirming the safety and effectiveness of COVID-19 vaccination during pregnancy, although it will also be necessary to determine the effectiveness of these vaccines specifically against newly emerging viral variants, including Omicron. In this Progress article, I cover recent developments in our understanding of the risks of SARS-CoV-2 infection in pregnancy, and how vaccination can reduce these.

SARS-CoV-2 感染会增加妊娠期间不良结局的风险，包括早产和死产。人们还越来越担心 SARS-CoV-2 感染对胎盘的影响，并且这些影响似乎因不同病毒变种而异。尽管存在这些风险，但出于安全考虑，许多孕妇仍不愿接种该病毒疫苗。我们现在拥有大量数据证实怀孕期间接种 COVID-19 疫苗的安全性和有效性，尽管还需要确定这些疫苗专门针对新出现的病毒变体（包括 Omicron）的有效性。在这篇进展文章中，我介绍了我们对妊娠期 SARS-CoV-2 感染风险的理解的最新进展，以及疫苗接种如何减少这些风险。