Sexual function is a vital aspect of human health and is recognized as a critical component of cancer survivorship. Understanding and evaluating the impacts of radiotherapy on female sexual function requires precise knowledge of the organs involved in sexual function and the relationship between radiotherapy exposure and sexual tissue function. Although substantial evidence exists describing the impact of radiotherapy on male erectile tissues and related clinical sexual outcomes, there is very little research in this area in females. The lack of biomedical data in female patients makes it difficult to design studies aimed at optimizing sexual function postradiotherapy for female pelvic malignancies. This scoping review identifies and categorizes current research on the impacts of radiotherapy on normal female erectile tissues, including damage to normal functioning, clinical outcomes of radiation-related female erectile tissue damage, and techniques to spare erectile tissues or therapies to treat such damage. An evaluation of the evidence was performed, and a summary of findings was generated according to Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Extension for Scoping Reviews guidelines. Articles were included in the review that involved normal female erectile tissues and radiotherapy side effects. The results show that little scientific investigation into the impacts of radiotherapy on female erectile tissues has been performed. Collaborative scientific investigations by clinical, basic, and behavioral scientists in oncology and radiotherapy are needed to generate radiobiologic and clinical evidence to advance prospective evaluation, prevention, and mitigation strategies that may improve sexual outcomes in female patients.

中文翻译：

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盆腔放疗后的女性勃起组织和性功能障碍：范围审查

性功能是人类健康的一个重要方面，被认为是癌症生存的重要组成部分。了解和评估放疗对女性性功能的影响需要精确了解与性功能有关的器官以及放疗暴露与性组织功能之间的关系。尽管存在大量证据描述放射治疗对男性勃起组织和相关临床性结果的影响，但在女性中这方面的研究很少。由于缺乏女性患者的生物医学数据，因此很难设计旨在优化女性盆腔恶性肿瘤放疗后性功能的研究。本范围审查对放射治疗对正常女性勃起组织影响的当前研究进行了识别和分类，包括对正常功能的损害、与辐射相关的女性勃起组织损害的临床结果，以及保护勃起组织的技术或治疗此类损害的疗法。对证据进行了评估，并根据系统审查和荟萃分析的首选报告项目（PRISMA）范围界定审查扩展指南生成了调查结果摘要。评论中包含涉及正常女性勃起组织和放射治疗副作用的文章。结果表明，关于放射治疗对女性勃起组织影响的科学研究很少。需要肿瘤学和放射治疗领域的临床、基础和行为科学家进行合作科学研究，以产生放射生物学和临床证据，以推进前瞻性评估，