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Genistein, a tool for geroscience
Mechanisms of Ageing and Development ( IF 5.3 ) Pub Date : 2022-03-17 , DOI: 10.1016/j.mad.2022.111665
Cristina Mas-Bargues 1 , Consuelo Borrás 1 , José Viña 1
Affiliation  

Geroprotection is defined as protection from the adverse effects of aging. The need for geroprotection implies changes towards individually tailored interventions that preserve an individual's independence, physical function, and cognition. Genistein, a phytoestrogen obtained from soya, has been reported to have beneficial properties on age-related diseases such as neurodegenerative and cardiovascular diseases or cancer. Indeed, genistein is a multimodal agent: it acts as a cancer protective agent, promoting apoptosis and cell cycle arrest, and inhibiting angiogenesis and metastasis, but it also acts as an antioxidant, anti-inflammatory, and anti-amyloid-β and autophagy promoter. Altogether, these properties make genistein a possible treatment for the specific aspects of age-related diseases such as hypertension, metabolic diseases, Alzheimer’s disease, and osteoporosis.



中文翻译:

金雀异黄素,一种老年科学工具

Geroprotection被定义为保护免受老化的不利影响。对老年保护的需求意味着对个体化干预的改变,以保持个体的独立性、身体机能和认知。据报道,染料木黄酮是一种从大豆中提取的植物雌激素,它对与年龄相关的疾病(如神经退行性疾病和心血管疾病或癌症)具有有益的作用。事实上,染料木黄酮是一种多模式药物:它作为一种癌症保护剂,促进细胞凋亡和细胞周期停滞,抑制血管生成和转移,但它也作为一种抗氧化剂、抗炎剂和抗淀粉样蛋白-β 和自噬促进剂. 总而言之,这些特性使染料木素成为治疗与年龄有关的疾病的特定方面的可能方法,例如高血压、代谢疾病、

更新日期:2022-03-17
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