当前位置: X-MOL 学术Nat. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immunomodulation by endothelial cells — partnering up with the immune system?
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2022-03-14 , DOI: 10.1038/s41577-022-00694-4
Jacob Amersfoort 1 , Guy Eelen 1 , Peter Carmeliet 1, 2, 3
Affiliation  

Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by regulating immune cell trafficking, activation status and function. However, whether the heterogeneous EC populations in various tissues and organs differ in their immunomodulatory capacity has received insufficient attention, certainly with regard to considering them for alternative immunotherapy. Recent single-cell studies have identified specific EC subtypes that express gene signatures indicative of phagocytosis or scavenging, antigen presentation and immune cell recruitment. Here we discuss emerging evidence suggesting a tissue-specific and vessel type-specific immunomodulatory role for distinct subtypes of ECs, here collectively referred to as ‘immunomodulatory ECs’ (IMECs). We propose that IMECs have more important functions in immunity than previously recognized, and suggest that these might be considered as targets for new immunotherapeutic approaches.



中文翻译:

内皮细胞的免疫调节——与免疫系统合作?

人们早就知道血管内皮细胞 (EC) 通过调节免疫细胞运输、激活状态和功能来调节炎症。然而,不同组织和器官中的异质 EC 群体是否在免疫调节能力方面存在差异尚未受到足够的重视,当然在考虑将它们用于替代免疫疗法方面。最近的单细胞研究已经确定了特定的 EC 亚型,这些亚型表达指示吞噬作用或清除、抗原呈递和免疫细胞募集的基因特征。在这里,我们讨论新出现的证据表明不同亚型的 ECs 具有组织特异性和血管类型特异性免疫调节作用,这里统称为“免疫调节 ECs”(IMECs)。

更新日期:2022-03-14
down
wechat
bug