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Associations of long-term physical activity trajectories with coronary artery calcium progression and cardiovascular disease events: results from the CARDIA study
British Journal of Sports Medicine ( IF 18.4 ) Pub Date : 2022-08-01 , DOI: 10.1136/bjsports-2021-105092
Jing-Wei Gao 1 , Qing-Yun Hao 1 , Liu-Yi Lu 2 , Jia-Jin Han 1 , Fei-Fei Huang 1 , Dominique A Vuitton 3 , Jing-Feng Wang 1 , Shao-Ling Zhang 4 , Pin-Ming Liu 5
Affiliation  

Objective The study aimed to assess the associations of physical activity (PA) trajectories across a 25-year span with coronary artery calcium (CAC) progression, and subsequent risk of cardiovascular disease (CVD) events. Methods We included 2497 participants from the Coronary Artery Disease Risk Development in Young Adults study who had computed tomography-assessment of CAC at baseline (year 15: 2000–2001) and follow-up (year 20 or 25) and at least three measures of PA from year 0 to year 25. Long-term PA trajectories were determined by latent class modelling using a validated questionnaire. Results Among the included participants, 1120 (44.9%) were men, 1418 (56.8%) were white, and the mean (SD) age was 40.4 (3.6) years. We identified three distinct PA trajectories based on PA average levels and change patterns: low (below PA guidelines, n=1332; 53.3%); moderate (meeting and slightly over PA guidelines, n=919; 36.8%) and high (about three times PA guidelines or more, n=246; 9.9%). During a mean (SD) follow-up of 8.9 (2.1) years, 640 (25.6%) participants had CAC progression. Participants in the high PA trajectory group had a higher risk of CAC progression than those in the low PA trajectory group after adjustment for traditional cardiovascular risk factors (HR 1.51; 95% CI 1.18 to 1.94). However, high PA trajectory was not associated with an increased risk of incident CVD events (HR 1.01; 95% CI 0.44 to 2.31) and the incidence of CVD events in participants with CAC progression was similar across all three PA trajectory groups (p=0.736). Conclusion Long-term PA about three times the guidelines or more is independently associated with CAC progression; however, no additional risk of incident CVD events could be detected. Data are available on reasonable request. Data may be obtained from a third party and are not publicly available. Data may be obtained from a third party and are not publicly available. Data are available upon request and data use agreement with the CARDIA study ().

中文翻译:

长期体力活动轨迹与冠状动脉钙化进展和心血管疾病事件的关联:CARDIA 研究的结果

目的 该研究旨在评估 25 年跨度的身体活动 (PA) 轨迹与冠状动脉钙 (CAC) 进展以及随后发生心血管疾病 (CVD) 事件的风险之间的关系。方法 我们纳入了来自年轻人冠状动脉疾病风险发展研究的 2497 名参与者,他们在基线(第 15 年:2000-2001 年)和随访(第 20 年或 25 年)进行了 CAC 计算机断层扫描评估,并至少进行了三个测量从第 0 年到第 25 年的 PA。长期 PA 轨迹是通过使用经过验证的问卷的潜在类别建模确定的。结果纳入的参与者中,男性1120人(44.9%),白人1418人(56.8%),平均(SD)年龄为40.4(3.6)岁。我们根据 PA 平均水平和变化模式确定了三个不同的 PA 轨迹:低(低于 PA 指南,n=1332;53.3%);中等(达到并略高于 PA 指南,n=919;36.8%)和高(大约是 PA 指南的三倍或更多,n=246;9.9%)。在 8.9 (2.1) 年的平均 (SD) 随访期间,640 (25.6%) 名参与者出现 CAC 进展。在调整传统心血管危险因素后,高 PA 轨迹组的参与者 CAC 进展风险高于低 PA 轨迹组的参与者(HR 1.51;95% CI 1.18 至 1.94)。然而,高 PA 轨迹与 CVD 事件风险增加无关(HR 1.01;95% CI 0.44 至 2.31),并且在所有三个 PA 轨迹组中,CAC 进展参与者的 CVD 事件发生率相似(p=0.736 )。结论 3 倍或以上指南的长期 PA 与 CAC 进展独立相关;然而,未检测到发生 CVD 事件的额外风险。可根据合理要求提供数据。数据可能从第三方获得,并且不公开。数据可能从第三方获得,并且不公开。数据可根据要求提供,并且与 CARDIA 研究达成数据使用协议()。
更新日期:2022-07-15
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