The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability.,Bone & Joint Research

当前位置： X-MOL 学术 › Bone Joint Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2022-3-12 , DOI: 10.1302/2046-3758.113.bjr-2021-0259.r1
Hasmik Jasmine Samvelyan _{1,

2,

3} , Carmen Huesa ₄ , Lin Cui ₅ , Colin Farquharson ₅ , Katherine Ann Staines _{1,

2}

Affiliation

Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here, we sought to examine the contribution of accelerated growth to OA development using a murine model of excessive longitudinal growth. Suppressor of cytokine signalling 2 (SOCS2) is a negative regulator of growth hormone (GH) signalling, thus mice deficient in SOCS2 (Socs2 ^-/-) display accelerated bone growth.

中文翻译：

在缺乏 SOCS2 的情况下加速生长板融合对骨关节炎易损性的作用。

骨关节炎 (OA) 是最普遍的全身性肌肉骨骼疾病，其特征是关节软骨退化和软骨下骨 (SCB) 硬化。在这里，我们试图使用过度纵向生长的小鼠模型来检查加速生长对 OA 发展的贡献。细胞因子信号转导抑制因子 2 (SOCS2) 是生长激素 (GH) 信号转导的负调节因子，因此缺乏 SOCS2 ( Socs2 ^-/- ) 的小鼠表现出加速的骨骼生长。

更新日期：2022-03-12

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>