Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the Na+/K+-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may Na+/K+-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP. cAMP-mediated Na+/K+-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.

中文翻译：

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cAMP 在长须蛉中肠中激活 Na+/K+-ATP 酶（Lutz & Neiva，1912；双翅目：Psychodidae）。

Lutzmyia longipalpis (Lutz & Neiva, 1912) 对雌性中肠 pH 值的调节进行了深入研究。pH调节所涉及的机制很复杂，有些方面仍有待阐明。在这里，我们研究了 Na+/K+-ATPase 泵作为电化学电位发生器的作用，以及雌性 L. longipalpis 中肠中第二信使 cAMP 对其的调节作用。我们的研究结果表明，Na+/K+-ATPase 不仅可能是雌性长须乳杆菌中肠跨膜电化学电位的主要产生者，而且其活性受到 cAMP 的正向调节。cAMP 介导的 Na+/K+-ATP 酶泵活性可能是维持血液消化过程中产生的营养物质运输所必需的。